Cognitive effects of ketamine and esketamine treatment for major depressive and bipolar disorder: a systematic review.
BACKGROUND Cognitive impairment is a core feature of major depressive disorder (MDD) and bipolar disorder (BD). Most conventional antidepressants do not have direct and clinically relevant procognitive effects. Ketamine and esketamine are effective in treating treatment-resistant depression (TRD). Herein, this systemat...