Memantine modulates TRPM3-associated glutamatergic signaling via vGLUT2 in a mouse model of obsessive-compulsive disorder.
Obsessive-compulsive disorder (OCD) is a chronic neuropsychiatric disorder involving neuroinflammation, glutamatergic dysregulation, and altered calcium signaling. Our recent work identified transient receptor potential melastatin 3 (TRPM3) channels as key contributors to OCD pathogenesis via modulation of neuroinflamm...