Author

Saeed Shirazian

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Open access Sep 2026

Artificial intelligence modeling of small molecule pharmaceutical solubility in supercritical fluid and comparative analysis under temperature and pressure variations

Enhancing the dissolution behavior of poorly water-soluble pharmaceuticals remains an important challenge in drug formulation and manufacturing, since limited aqueous solubility can substantially restrict therapeutic performance. Supercritical-fluid technologies provide a promising route for addressing this limitation,...

Hao-Lin Wu, Hadil Faris Alotaibi, A. S. Fahem et al. · Frontiers in Chemistry · 0 citations

Open access Aug 2026

Drugs solubility parameter prediction using modified Cubic Plus Chain equation of state.

The proposed CPC-TST model demonstrated good accuracy in predicting solubility parameter, particularly for strongly associating systems, while maintaining low computational complexity, and highlights the potential of the CPC-TST model as a robust and efficient alternative for modeling solubility behavior in pharmaceuti...

A. S. Alqahtani, Saeed Shirazian · European Journal of Pharmace... · 0 citations