Obtaining high-quality single-cell suspensions from neural tissues such as the murine retina remains technically challenging due to cellular fragility, tight intercellular junctions, and the heterogeneous composition of the tissue. These challenges are further compounded when studying rare cell populations, including v...
J. Fleischer, Melanie E. Schwämmle, Jan N. Ness et al.· Journal of Visualized Experi...· 0 citations
Radiotherapy (RT) combined with PD-1/PD-L1 blockade can induce systemic antitumor responses, but robust control of distant lesions remains uncommon. We identified a quadruple regimen combining immunogenic hypofractionated RT (hRT; 8 Gy × 3) to the primary tumor, low-dose RT (LDRT; 3 Gy × 3) to the secondary tumor, anti...
Mei-Dan Wang, Li-Qun Wang, Sagar et al.· Cancer Letters· 0 citations
This work investigated how elimination of murine MHC together with different conditioning regimens shapes human T-cell maturation in vivo, and revealed marked differences in T-cell differentiation across models.
M. Darguzyte, Ж. Ш. Жумадилова, F. Khan et al.· bioRxiv· 0 citations
The mouse epidermis harbors two key resident immune populations—dendritic epidermal T cells (DETCs), a subset of invariant γδ T cells, and Langerhans cells (LCs), specialized tissue-resident macrophages—both of which play critical roles in immune surveillance, barrier integrity, and tissue homeostasis. While their feta...
D. Obwegs, Alexander Oschwald, L. Koetter et al.· Science Advances· 0 citations
We use cookies to run the site and, with your consent, for analytics and to show ads.
See our Cookie Policy.