Sagar Bhattacharya

Conserved catalytic motifs encode enzyme-like supramolecular peptide assemblies

A seven-residue fragment derived from the active-site region of carbonic anhydrase spontaneously forms Zn2+-binding amyloid fibrils that catalyze carbon dioxide hydration with catalytic efficiencies surpassing all previous carbonic anhydrase mimics and approaching those of natural enzymes. Cryo-electron microscopy at 2...