Sep 2026
Octreotide mitigates cisplatin-induced nephrotoxicity through coordinated modulation of the miR-34a/SIRT1 axis and downstream apoptotic, inflammatory, and fibrotic pathways.
AIMS Cisplatin (CIS) is a widely used chemotherapeutic agent, but its clinical utility is limited by dose-dependent nephrotoxicity. Octreotide (OCT), a somatostatin analog, exhibits anti-inflammatory, antioxidant, and anti-apoptotic properties in several experimental models, yet its therapeutic potential against cispla...
M. Ghoneim, Yousra Y. El Banna, Mohamed H. Noureldin et al.
· Life Science · 0 citations