Mitochondrial Calcium Dysregulation: A Central Nexus in Alzheimer’s Disease Pathogenesis and Therapeutic Intervention
Research in Alzheimer’s disease (AD) has been primarily focused on the genetic causes and therapies to target the amyloid‑β (Aβ) plaques and neurofibrillary tau tangles (NFTs). However, a growing body of research suggests that imbalances and subsequent breakdown in mitochondrial calcium (Ca²⁺) regulation plays a centra...