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Author

Sai Ma

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Open access Sep 2026

A CRISPR-Based Humanized Model Reveals Cooperative Role of STAG2 Loss in Familial GATA2-Deficient MDS Progression.

This humanized model faithfully recapitulates high-risk GATA2-deficient Myelodysplastic syndrome with acquired STAG2 loss, providing mechanistic insight into how cooperative mutations drive stem cell expansion, inflammatory signaling, and myeloid skewing.

Grace S. Freed, Miguel Quijada-Álamo, Linda Lee et al. · 0 citations
Open access Jul 2026

Uhrf1 loss disrupts Ctcf-associated chromatin organization during early mouse embryogenesis

These findings identify Uhrf1 as a central regulator that tightly couples DNA methylation maintenance to 3D genome organization during gastrulation, thereby, directing early lineage specification and positioning Uhrf1 as a pivotal mediator of epigenetic information transfer during early embryogenesis.

Agata Kurowski, Bohan Zhu, Yifei Sun et al. · 0 citations

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