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Saima Kalsoom

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Open access Sep 2026

Integrated computational and experimental studies on benzothiazine–chalcone hybrids: Crystal Structures, in silico modeling, and in vitro evaluation of α-glucosidase inhibition and antioxidant activity

The pharmacophore fusion approach is a well-established strategy in drug discovery for designing new pharmacophores from the existing pharmacophores with potential biological applications. The 1,2-benzothiazine based ketone is condensed with halogenated aldehydes to isolate 1,2-benzothiazine hybrid chalcones. These c...

A. Ashraf, W. Siddiqui, M. Arshad et al. · 0 citations
Open access Aug 2026

Sabinene attenuates inflammation and oxidative stress in CFA-induced arthritis: In vivo and in silico evidence implicating TLR4/NLRP3/NF-κB signaling.

Findings support a prophylactic protective effect of sabinene against CFA-induced arthritis associated with reduced inflammation, improved antioxidant status, and modulation of inflammasome-related gene expression.

Kanwal Asif, Ambreen Malik Uttra, Arham Shabbir et al. · 0 citations

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