Evaluation of the effects of alpha-lipoic acid on cyclosporine-induced memory dysfunction and cellular immunosuppression in rats.
BACKGROUND AND PURPOSE Cyclosporine A (CsA) is used to control autoimmune reactions and prevent organ rejection, but its clinical application is limited by neurotoxicity and nephrotoxicity. This study investigated the neuroprotective effects of alpha-lipoic acid (ALA), an antioxidant, anti-inflammatory, and immunomodul...