Saketh Chemuru

Mass Spectrometric Footprinting and DFT Calculations Explain the Effect of Curcumin on the Aggregation of Amyloid β 42 (Aβ42).

Curcumin, a polyphenolic natural product, binds to Aβ42, a protein involved in Alzheimer's Disease, to inhibit self-aggregation in vitro. Molecular understanding of the binding is important in designing new molecules to inhibit Aβ42 aggregation. We performed OH radical footprinting of Aβ42 in the presence and absence o...