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Author

Saki Matsumoto

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Open access Oct 2026

Engineering T cell-engaging bispecific antibodies targeting KRAS G12V neoantigen across HLA-A*11:01 and HLA-A*03:01

Abstract Background T cells recognize tumor-specific neoantigens presented by human leukocyte antigen (HLA) molecules and can mediate potent antitumor immunity. However, most neoantigens are patient-specific, limiting their broad therapeutic applicability. KRAS G12V is a recurrent oncogenic mutation found in multiple c...

Xiao-Jing Wu, Clara Effenberger, Yosuke Matsushita et al. · 0 citations

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