Open access
Sep 2026
The GSEC-encoded polypeptide GESP drives colorectal cancer tumorigenesis via NPM1-c-Myc-mediated repression of NDRG1.
Expression of long non-coding RNAs (lncRNAs) is frequently dysregulated in human cancers. We previously reported that the lncRNA GSEC accelerates colorectal cancer (CRC) cell motility by inhibiting the RNA helicase DHX36. Here, we demonstrated that a nuclear polypeptide (designated 'GESP') is translated from a short OR...
Y. Kawasaki, Tomoatsu Hayashi, Akane Kitta-Kunihiro et al.
· Oncogene · 0 citations