Author

Sakuni Rankothgedera

2 papers indexed here

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Open access Sep 2026

Atlas-Guided Cell-Specific Transcriptomics Identifies Pathway-Level Remodeling of Human Hypothalamic CRH Neurons in Opioid Use Disorder

Opioid use disorder (OUD) disrupts hypothalamic stress signaling, yet the molecular state of human paraventricular nucleus (PVN) corticotropin-releasing hormone (CRH) neurons remains poorly defined. Using single-nucleus RNA sequencing of 343,819 human hypothalamic nuclei, we applied complementary human HYPOMAP/MapMyCel...

Lorna Barrall, Phillip Urbanczyk, Bruno Kluwe-Schiavon et al. · bioRxiv · 0 citations

Open access Jul 2026

The CD83 axis between Tregs and CCR7+ dendritic cells governs anti-tumor immune responses 2309951

This study demonstrates that the ablation of interaction of CD83 molecule between CCR7+DC and Tregs results in increased anti-tumor immune response, and identifies CD83 as a cellular and molecular checkpoint that restrains T cell responses and can be targeted therapeutically.

Ruparoshni Jayabalan, Ricardo Gonzalez-Delgado, Luis A. Castillo Montanez et al. · Journal of Immunology · 0 citations