Dual-therapeutic niraparib-loaded chitosan nanoparticle-alginate hydrogel with adipose-derived stromal cells promotes functional and histological recovery after spinal cord injury.
BACKGROUND Spinal cord injury (SCI) triggers oxidative stress, inflammation, and progressive neurodegeneration. METHODS Here, we developed a dual-therapy composite hydrogel that integrates niraparib-loaded chitosan nanoparticles (NICNPs) and adipose-derived stromal cells (ASCs) into a calcium alginate scaffold for su...