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Author

Samaneh Sharif

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2026

Allele-specific disruption of KRAS p.G12V in colorectal cancer cells using electroporated Cas9 RNPs

Objective(s): Colorectal cancer (CRC) is a major cause of mortality, and KRAS mutations drive tumorigenesis and therapy resistance. Although CRISPR-Cas9 enables precise genome editing, intracellular delivery of Cas9 ribonucleoproteins (RNPs) remains challenging. We evaluated direct electroporation of Cas9-sgRNA RNPs ta...

Firouzeh Morshedzadeh, Samaneh Sharif, M. Peymani et al. · 0 citations

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