O'6-methylguanine-DNA methyltransferase methylation status in canine intracranial glioma tissue samples
Gliomas are the second most common intracranial malignancy in dogs. Methylation of the CpG island of the MGMT (O6-methylguanine-DNA-methyltransferase) gene has been associated with an increased clinical response to temozolomide in human glioma. CpG island methylation can silence a gene responsible for a pathway of DNA...