Author

Samantha L. Schuster

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Open access Oct 2026

Dysregulation of epithelial differentiation architecture underlies field cancerization in head and neck cancer

Head and neck squamous cell carcinoma (HNSCC) has exceptionally high recurrence rates, exceeding 50%, contributing to mortality and morbidity. This recurrence rate is proposed to be due to field cancerization, a phenomenon where tumor-adjacent “field” tissue that appears histologically normal harbors molecular changes...

Claire B. Mills, Yin Huang, Chan-Mi Lee et al. · bioRxiv · 0 citations

Open access Oct 2026

tRNA dosage regulates lineage dependency and resistance in prostate cancer.

Lineage plasticity underlies therapeutic resistance in cancer1,2, yet the translational mechanisms that enable this phenotypic flexibility remain largely unknown. Here using prostate cancer as a model of lineage dependence, we performed unbiased small RNA sequencing and identified tRNA1Arg(UCU) as a regulator of lineag...

Y. Kim, Sonali Arora, D. Young et al. · Nature · 0 citations

Open access Sep 2026

Evolution and heterogeneity of lethal metastatic bladder cancer subtypes

It is shown that metastasis-to-metastasis seeding is the dominant pattern of cancer spread and that increased polyclonal migration predicts poor prognosis, and that post-mortem cell-free DNA captures genomic and transcriptional heterogeneity of the subtypes, which provides a potential strategy for noninvasive assessmen...

P. Itagi, Samantha L. Schuster, Sonali Arora et al. · Nature · 0 citations