Samantha Nasser

Enhanced Fidelity and Sequence Generality of an RNA Polymerase Ribozyme

Directed evolution has been used to develop RNA enzymes (ribozymes) that catalyze the RNA-templated polymerization of RNA. The more advanced polymerases can synthesize long RNA products, but have shortcomings with regard to copying accuracy and template sequence generality, which are impediments to using the polymerase...