Samantha S. Watson

Organic Cosolvent-Free Antibody–Drug Conjugation Enabled by Hydrophilic Linker–Payloads

Bioconjugation of linker–payloads (LPs) to antibodies has historically relied on organic cosolvents or surfactants to overcome the poor aqueous solubility of cytotoxic payloads─an assumption that has remained largely unquestioned in antibody–drug conjugate (ADC) manufacturing. Here, we systematically re-evaluate this...