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Author

Samuel Holvec

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Open access Jul 2025

Translation initiation by the Kozak mRNA sequence is based on a conformational readout on the ribosome

The cryo-EM structures of human 48S preinitiation complexes with mRNA point mutations reveal a fan-like intercalation of the pre-codon triplet into the 18S ribosomal RNA (rRNA), while the -3 purine as opposed to the pyrimidine in the non-Kozak context favours stabilization of the ternary complex between initiation fact...

O. von Loeffelholz, Charles Barchet, Samuel Holvec et al. · 2 citations

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