Samuel Ruesga Mundo

Neuroinflammation as a failure of allostatic integrity: a hierarchical-circular model of biological memory for pathogenesis in neurodegenerative and neuropsychiatric diseases

Introduction Chronic neuroinflammation is a hallmark of neurodegenerative diseases (Alzheimer’s disease, Parkinson’s disease) and neuropsychiatric disorders (major depression, schizophrenia). However, current models fail to explain why some individuals develop persistent neuroinflammation while others maintain homeosta...