Open access
Oct 2026
Syntaxin11 deficiency inhibits CRAC channel priming to suppress cytotoxicity and gene expression in T lymphocytes independent of membrane trafficking
It is shown that STX11 directly binds and regulates Orai1, the pore-forming subunit of calcium release-activated calcium (CRAC) channels, and ‘primes’ Orai1 for optimal on-site multimeric assembly, which was Stim independent but required for gating.
Sritama Datta, Abhikarsh Gupta, K. M. Jagetiya et al.
· eLife · 0 citations