Open access
Jul 2026
Integrated single-cell and spatial transcriptomics reveals a multicellular program contributing to immunotherapy resistance and adverse clinical outcomes in clear cell renal cell carcinoma.
This study defines a spatially organized, functionally coordinated multicellular niche that drives ICB resistance in ccRCC, establishing both a predictive biomarker for patient stratification and a mechanistic framework for therapeutic intervention.
Wen-Bin Yao, Jia Qi, Xinyi Zheng et al.
· npj Precision Oncology · 0 citations