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Author

Sang Keun Ha

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Open access Sep 2026

Nε-(Carboxymethyl)lysine induces mitochondrial stress, inflammatory activation, and fibrogenic remodelling in multicellular human liver organoids.

Advanced glycation end-products (AGEs) accumulate in metabolic dysfunction-associated steatotic liver disease (MASLD); however, the contribution of individual AGE species remains poorly defined. We focused on Nε-(carboxymethyl)lysine (CML), a well-characterised AGE generated through glycoxidation and lipid peroxidation...

Jin-Young Min, Min-Ji Gu, Hye Min Kim et al. · 0 citations
Open access Oct 2026

Anti-Glycation And Metabolic Protective Effects of Petasites japonicus Maxim Leaf Extract in Methylglyoxal-Drinking Mouse Model Through Attenuation of Advanced Glycation End Products Accumulation

Methylglyoxal (MGO) is a highly reactive dicarbonyl compound that promotes formation of advanced glycation end products (AGEs) and protein cross-linking, thereby contributing to metabolic dysfunction and insulin resistance. In this study, we investigated the anti-glycation effects of Petasites japonicus Maxim leaf (PJL...

Jin-Ah Lee, Min-Ji Gu, Yu-Ra Lee et al. · 0 citations

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