Jul 2026
RepID orchestrates CDH1 and CTNNB1 homeostasis to regulate metastatic potential in small cell lung cancer.
These findings establish RepID as a previously unrecognized molecular rheostat that constrains SCLC metastatic potential by integrating transcriptional regulation of epithelial integrity with post-translational control of the CRL1-CTNNB1 axis, providing a potential therapeutic vulnerability in recalcitrant SCLC.
Dong-Kyu Kim, Jae-Hyun Jo, Jong-Uk Park et al.
· Biochemical and Biophysical... · 0 citations