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Sep 2026

Tetracyclic pyrazinocarbazole derivatives as YAP-TEAD pathway inhibitors with activity in a melanoma lung colonization model.

Direct pharmacological disruption of the YAP-TEAD transcriptional complex is a promising strategy for Hippo pathway-driven cancers, but chemically tractable small-molecule chemotypes with in vivo activity remain limited. Here, we describe the optimization of a pirlindole-derived tetracyclic pyrazinocarbazole scaffold t...

Xiang Fei, Sanha Lee, Chaelin Lee et al. · 0 citations
Preprint Sep 2026

Facilitated Exclusion Process in Higher Dimensions: Recurrent Structure and Transient Dynamics

In this article, we study the facilitated exclusion process (FEP) on the $d$-dimensional discrete torus of side length $N$, with $d\ge2$. For Bernoulli initial data with a fixed density $\rho\in(0,1)$, we first prove that, with high probability, the particle-number sector selected by the initial configuration has a uni...

Seonwoo Kim, Sanha Lee, Insuk Seo · 0 citations

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