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Sanskruti Sharma

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Oct 2026

PBPK Modeling of Varenicline: Relating Variable Pharmacokinetics to Genomics.

Individuals with high varenicline exposure may have reduced renal elimination due to genetic variation in SLC22A2 (OCT2), while those with higher Cmax may have elevated intestinal pH, giving a higher level of neutral varenicline.

Sanskruti Sharma, Ian S. Haworth · 0 citations

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