Open access
Sep 2026
DFCP1-containing ER microdomains mediate lysosomal membrane repair
Lysosomal membrane integrity is essential for preserving cellular homeostasis in response to different stressors. Upon lysosomal membrane permeabilization, cells activate several mechanisms for lysosomal membrane repair, including ESCRT proteins, phosphatidylinositol 4-phosphate (PI4P)-dependent lipid transfer from the...
Maja Radulovic, S. Pust, Athanasios Kournoutis et al.
· Nature Cell Biology · 2 citations