Higher levels of peripheral pro-inflammatory markers are associated with white matter microstructure associated with multi-shell dMRI Neurite Orientation Dispersion and Density Imaging (NODDI), supporting the sensitivity of these dMRI-based metrics to inflammatory processes.
Siona Mishra, C. Pettigrew, Chidi Ugonna et al.· Neurobiology of Aging· 0 citations
BACKGROUND
Demonstrating the specificity of plasma biomarkers to AD-related neurodegeneration would add support to their prognostic and diagnostic clinical use.
METHOD
Participants from the Baltimore Longitudinal Study of Aging were cognitively unimpaired at the time of their plasma Aβ42/Aβ40, GFAP, NfL (Quanterix Ne...
Murat Bilgel, Ishaan Shah, Jasmine M. Cooper et al.· Alzheimer's & Dementia· 0 citations
Among CU individuals, plasma p-tau217 was associated with subsequent MCI/dementia due to AD and showed the most extensive associations with longitudinal AD-related brain atrophy, compared with SPARE-BA or R-indices capturing subcortical, diffuse cortical, or perisylvian atrophy.
Murat Bilgel, Ishaan Shah, Jasmine M. Cooper et al.· medRxiv· 0 citations
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