Open access
Jul 2026
Lactate-induced H3K4me3 histone mark promotes PLOD1-driven prostate cancer invasion
The findings uncover a novel LA-fuelled metabolic-epigenetic axis that promotes the H3K4me3-mediated PLOD1 upregulation, consequently fostering PCa aggressiveness and unveiling a potential therapeutic vulnerability.
Marta Iozzo, Luigi Ippolito, E. Pranzini et al.
· Cell Death and Disease · 0 citations