Open access
Aug 2026
Modeling maternal immune activation in 3D ex vivo human fetal brain cerebroids reveals IL-17A-driven disruption of cortical development
Maternal immune activation (MIA) disrupts brain development and increases the risk of neurodevelopmental disorders, yet the mechanisms by which MIA impacts human cortical development remain poorly understood. Here we introduce a three-dimensional ex vivo culture system, termed ‘cerebroids,’ derived from the dorsolatera...
Muhammad Z. K. Assir, Mario Yanakiev, Do Hyeon Gim et al.
· Nature Neuroscience · 0 citations