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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

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Sarah A. Looby

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Open access Sep 2026

Best practices for isothermal titration calorimetry of protein–DNA interactions

Isothermal titration calorimetry (ITC) is a powerful label-free method for quantifying protein–DNA interactions, providing direct measurements of binding affinity, stoichiometry, enthalpy, and entropy in a single experiment. However, the quality of protein–DNA ITC data depends strongly on experimental details, includin...

F. Mekkaoui, Sarah A. Looby, Lauren N. Merrikin et al. · 0 citations

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