Open access
Oct 2026
Spatiotemporal co-regulation of IL2 and TCR receptors reveals early antigen-driven synaptic synergy in human CD8+ T cells
Interleukin 2 (IL2) promotes T cell proliferation and differentiation, making it a central target in immunotherapies. Following antigen recognition, IL2 receptor (IL2R) signaling polarizes towards the immunological synapse (IS). However, how IL2 function is integrated during earlier antigen-dependent T cell synapse...
J. Capera, María Navarro-Pérez, Ashwin K. Jainarayanan et al.
· Nature Communications · 0 citations