Sarah Grambo

Distinct Evolutionary Selection Patterns in Temperate and Filamentous Phages of Phocaeicola vulgatus in Health and IBD

The gut virome is profoundly altered in inflammatory bowel disease (IBD), though phage evolution during inflammation remains poorly understood. We used viral tagging (VT) to recover phages of Phocaeicola vulgatus, a gut-associated pathobiont, from healthy and Crohn’s disease (CD) viromes, revealing phages related to th...