Sarah Leclercq

Amplification of seeding-competent tau aggregates by PMCA in human and experimental tauopathies

Tau assemblies, associated with tauopathies, are believed to self-propagate through prion-like mechanisms in the central nervous system, driving neurodegeneration. Recently, protein seed amplification assays have emerged as highly sensitive methods for detecting trace amounts of misfolded protein assemblies across vari...