Author

Sarah Nickels

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Open access Jul 2026

Interpretable gene networks from single-cell foundation models reveal conserved neurogenic dysfunction in Parkinson’s disease

Interpreting large-scale single-cell transcriptomic data remains a major challenge for understanding disease mechanisms. Recent single-cell foundation models learn rich representations of gene relationships across millions of cells, yet methods for translating these embeddings into biologically interpretable gene netwo...

Jun Yin, Maya L. Gosztyla, Birkan Gokbag et al. · bioRxiv · 0 citations

Open access Aug 2026

LRRK2-G2019S impairs astrocyte differentiation and triggers a senescence-like phenotype in Parkinson’s disease models

Data show that LRRK2-G2019S impairs astrocyte specification and predisposes to a senescent phenotype, which contributes to the acquisition of a senescent-like phenotype in Parkinson’s disease patients.

Lisa M. Smits, S. Magni, K. Grzyb et al. · npj Parkinson's Disease · 0 citations