Author

Sarath Perumal

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Open access Sep 2026

Template‐Derived Engineering of Peptide Inhibitors Targeting HSP90–CDC37 Interface: A Theoretical Framework for Cancer Therapeutics

The HSP90–CDC37 complex plays a key role in stabilizing multiple oncogenic client proteins, thereby sustaining cancer cell survival. However, targeting these dynamic interfaces remains challenging due to the large, shallow binding surfaces, which limit the effectiveness of conventional small‐molecule inhibitors. Pept...

Sarath Perumal, Ramanathan Karuppasamy · ChemistrySelect · 0 citations

Open access Aug 2026

Design and development of novel peptidomimetic compounds for cancer therapeutics: Focus on HSP90–CDC37 interaction

Background: The HSP90 and CDC37 molecular chaperone complex governs the stability and function of numerous client protein kinases, making it a crucial cancer target. Given their central role, disrupting this interaction induces proteotoxic stress and inhibits tumor progression. Therapeutic peptides are the mainstay of...

Sarath Perumal, Ramanathan Karuppasamy · BioMedicine · 0 citations