Open access
Sep 2026
Atomistic TCR-pMHC interactions bias CD8 memory fate within a single antigen-specific repertoire.
Memory CD8 T cells provide durable protection against recurrent infection and cancer, but how individual TCR clonotypes contribute to distinct memory fates remains enigmatic. Here, we analyzed 242 murine CD8 TCRαβ clonotypes specific for an influenza NP366-374/H-2Db ligand (pMHC) by integrating single-cell transcriptom...
Akitsu Aoi, Ke-Min Tan, R. Mallis et al.
· Cell Reports · 0 citations