Design and optimization of Pt@ZIF-8 nanostructures via QbD approach: structural characterization and cytotoxic insights
Platinum nanoparticles (Pt NPs) exhibit inherent anticancer properties; however, their therapeutic application is limited by poor colloidal stability, ineffective cellular uptake, and inconsistent formulation reproducibility. While zeolitic imidazolate framework-8 (ZIF-8) has shown promise as a pH-responsive nanocarrie...