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Author

Sason Shaik

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Aug 2026

Metal Coordination Dynamics Governs Selective Halogenation in α-KG/Fe-Dependent Halogenase SyrB2.

α-Ketoglutarate (α-KG)-dependent nonheme iron enzymes catalyze a diverse array of oxidative transformations essential for natural product biosynthesis. However, the mechanism by which α-KG/Fe-dependent halogenases achieve selective halogenation while circumventing the thermodynamically favored hydroxylation pathway rem...

Wen-Li Yuan, Jia-Yong Huang, Jia Liu et al. · 0 citations

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