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Satoshi Baba

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Open access Sep 2026

Automated zonal-rotor CsCl ultracentrifugation with ÄKTA-based fractionation removes empty and intermediate AAV capsids

Recombinant adeno-associated virus (AAV) preparations contain heterogeneous full, empty, and intermediate capsids. Although anion-exchange chromatography is scalable, it does not always resolve these populations, particularly intermediate capsids. A workflow integrated zonal-rotor cesium chloride (CsCl) density-gradien...

Kosuke Horita, Ryuki Miyauchi, Hideaki Yamamoto et al. · 0 citations

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