Author

Saumya Saurabh

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Open access Sep 2026

Multiparametric microenvironment sensing via distinct molecular equilibria in a single cyanine dye

Reading both physical and chemical properties of a microenvironment from a single fluorophore remains a challenge. Here we demonstrate that two coexisting molecular equilibria within one near-infrared cyanine, CyC4, encode two mechanistically distinct ratiometric reporting channels. A meso-amino group and a pendant car...

Sujata Bais, Soren Westrey, C. López et al. · bioRxiv · 0 citations

Open access Jun 2025

Bacterial ribonucleoprotein bodies maintain an acidic pH environment as a mechanism of enzyme regulation

Phase separated biomolecular condensates create subcellular niches, yet their role in client regulation remains unclear. Here, we demonstrate that Bacterial Ribonucleoprotein bodies (BR-bodies) are acidic. Using ratiometric fluorescent probes in vivo, we find BR-bodies exhibit a dense-phase pH of ∼5.1, significantly lo...

Wade E. Schnorr, Moeka Sasazawa, Kathryn G. Dzurik et al. · bioRxiv · 0 citations

Open access Aug 2026

Aminoglycoside antibiotics drive RNA phase separation

It is shown that aminoglycosides are a class of small-molecule RNA condensers, and neomycin B (neoB), an FDA-approved member of the family, is taken as a representative drug through which to dissect the mechanism.

Julian von Hofe, Mechi Chen, Christine Choi et al. · bioRxiv · 0 citations