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Author

Savannah Harris

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Open access Aug 2026

Dual Targeting of FGFR4 and PI3K–mTOR Suppresses Tumor-Associated Phenotypes in Pancreatic Ductal Adenocarcinoma

Dual pathway inhibition consistently and additively suppressed tumor-associated phenotypes despite compensatory MAPK activation, with the clearest added benefit over fisogatinib alone in migration, cell-cycle control, and 4E-BP1 modulation, supporting translational regulation as a shared therapeutic vulnerability.

Joseph A. Goode, Savannah Harris, D. Altomare · 0 citations

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