Author

Sayaka Tojima

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Open access Sep 2026

Three-dimensional imaging reveals distinct muscle-vessel-nerve relationships during dorsal and ventral muscle splitting in the chicken forelimb

During vertebrate limb development, muscles, blood vessels, and nerves undergo coordinated morphogenesis. Limb muscles form through progressive splitting of the dorsal and ventral muscle masses, but the three-dimensional relationships between muscle splitting and surrounding tissues remain incompletely understood. Alth...

Yuta Takase, Sayaka Tojima · bioRxiv · 0 citations

Open access Jul 2026

Disruption of Histone H4C genes impairs skeletal development and cortical neurogenesis, modeling rare neurodevelopmental syndromes

It is demonstrated that histone H4C genes play crucial roles in skeletal development and cortical neurogenesis and suggest that histone H4 plays a critical role in regulating the balance between proliferation and differentiation during mammalian embryonic development, thereby explaining the broad spectrum of patient ph...

Haruna Nagasawa, Kaneyasu Nishimura, Sayaka Tojima et al. · bioRxiv · 0 citations