Author

Scott H. Kaufmann

2 papers indexed here

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Open access Sep 2026

BCLXL blockade rewires cell fate to overcome PARP inhibitor resistance in ovarian cancer

Poly(ADP-ribose) polymerase (PARP) inhibitors (PARPis) induce regressions and extend progression-free survival (PFS) in ovarian cancer, especially in tumors with BRCA1 or BRCA2 mutations that impair homologous recombination repair. While recent studies have clarified the key roles of BRCA1, BRCA2, and PARP1 in replicat...

A. Venkatachalam, Annabella R. Strathman, Xia Hou et al. · Signal Transduction and Targ... · 0 citations

#machine learning Preprint Sep 2026

Morphology signal in whole slide image foundation models can automatically triage slides

Evaluations show that ranking WSIs based on predictions from zero-shot classification using WSI FMs accurately identifies slides with the most tumor, indicating that WSI FMs contain sufficient morphology signal to automatically triage slides.

Ayushi Sinha, Shashank Yadav, Benjamin Holmes et al. · 0 citations