Elucidation of hydrogen bonding networks in theophylline cocrystals by 1H-detected 17O and 14N solid-state NMR spectroscopy
Determining hydrogen bonding networks and proton positions in pharmaceutical cocrystals remains challenging, particularly for microcrystalline materials and systems involving strong hydrogen bonds and partial proton transfer. Here, we demonstrate a strategy that combines fast magic-angle spinning (MAS) solid-state NMR...