Human diet and lifestyle vary widely across cultures, shaping global diversity in gut microbiome composition and function. However, comparable cross-population studies have been limited by methodological heterogeneity. The Human Diets and Microbiome Initiative (THDMI) integrates standardized recruitment, dietary asse...
Lora Khatib, Renee E. Oles, Alejandra Ríos Hernández et al.· Nature Communications· 0 citations
It is demonstrated that transformer derived surprisal systematically distinguishes functionally constrained sequences from unconstrained ones across digital and biological substrates, establishing transformer surprisal as a potential measure of functional information in evolving systems.
Tyler D. Myers, Se-Jin Song, A. Bartko· IEEE Symposium on Artificial...· 0 citations
Results demonstrate that CIS exhibits significant intra-patient heterogeneity not captured by single-site profiling, and support multi-region sampling, which could help improve risk stratification, biomarker development, and prediction of response to intravesical therapies.
Tyler D. Myers, A. Salmasi, M. Meagher et al.· bioRxiv· 0 citations
Joint Robust Principal Component Analysis (Joint-RPCA), a method designed with these statistical properties in mind and broadly applicable to multi-omics settings with similar challenges, reveals replicable and interpretable multi-omic patterns.
Bianca Cordazzo Vargas, C. Martino, A. Dilmore et al.· Molecular Systems Biology· 1 citation
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