The continued emergence of betacoronaviruses underscores the urgent need for vaccines that provide broadly protective immunity. Here, we present an epitope-focused vaccine strategy targeting the conserved S2 stem-helix region of the spike fusion machinery, a broadly neutralizing antibody-(bnAb) epitope shared across be...
Panpan Zhou, Ziqi Feng, Wan-ting He et al.· bioRxiv· 0 citations
The isolation of a human monoclonal antibody from a SARS-CoV-2 convalescent donor that targets the conserved S2 stem helix region is reported, demonstrating the potential of in vitro affinity maturation to expand the neutralization breadth of stem-helix-targeting antibodies across divergent betacoronaviruses.
Panpan Zhou, M. Yuan, Yue-Xiu Zhang et al.· PLoS Pathogens· 0 citations
The AIntibody challenge shows that AI can optimize antibodies in defined, biologically grounded regimes, in addition to highlighting critical gaps including affinity prediction and library-inspired antibody design and cross-task generalization.
M. Erasmus, Daniel Bedinger, Elizabeth Hopkins et al.· Nature Biotechnology· 0 citations
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