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Author

Sean-Luc Shanahan

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Jul 2026

Neoantigen-specific CD4+ T cells sustain endogenous intratumoral B cell responses to enhance anti-tumor immunity 2258511

Cancer mutations can give rise to novel tumor-specific peptides (“neoantigens”) that are recognized by T cells to attack tumors. CD4+ T cells cooperate with B cells of related antigen specificity to promote antibody production and enhance antitumor immunity. Paradoxically, tumors are frequently coated with mature...

D. Klawon, Shalom Beyene, Sean-Luc Shanahan et al. · 0 citations

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